|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We observed that the R702W and 1007fs Nod2 alleles and the A299G Tlr4 alleles were significantly more prevalent in patients with CD as compared to healthy controls or patients with ulcerative colitis.
|
16010583 |
2005 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We investigated polymorphisms of CARD15, TLR4, and OCTN, and environmental factors in a monozygotic twin pair with Crohn's disease and their first-degree relatives.
|
16024933 |
2005 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We have reported on a novel association of the TLR4 Asp299Gly polymorphism with both CD and UC.
|
15194649 |
2004 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Toll-like receptor (TLR) polymorphisms, and especially TLR-4 Asp299Gly and TLR-4 Thr399Ile, have been linked with Crohn's disease (CD) and to a lesser extent with ulcerative colitis (UC), CD behavior, and compromised seroreactivity to microbial antigens.
|
22918682 |
2013 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To examine whether TLR4 Asp299Gly, CD14-260C/T, TNF-1031T/C, TNF-863C/A, TNF-857C/T, TACE-172C/T, and TACE-154C/A polymorphisms are associated with Crohn disease in the Ashkenazi Jewish population, we analyzed families with at least 1 child with Crohn disease for association with these mutations using a family-based association test (transmission disequilibrium test) for analysis.
|
18493210 |
2008 |
|
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
this study reported the absence of association between CD and TLR4 gene in the Tunisian population, but this gene could play a role in clinical expression of the disease.
|
19664207 |
2009 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This genetic study provides evidence that the three major CARD15/NOD2 variant alleles and the CD14 -159C/T polymorphism are associated with Crohn's disease (CD) susceptibility in the Saudi population; however, there is no evidence that the TLR4 (Thr399Il) or CARD15/NOD2 polymorphisms can be considered risk factors for Crohn's disease.
|
22605977 |
2012 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/CARD15, but not TLR4 SNPs, are associated with increased risk of CD.
|
18680223 |
2008 |
|
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Therapeutic effect of Brucea javanica oil emulsion on experimental Crohn's disease in rats: Involvement of TLR4/ NF-κB signaling pathway.
|
30901719 |
2019 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.
|
24971461 |
2014 |
|
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
The patients with CD were characterized by a significantly higher monocyte basal expression of TNF-α compared with healthy subjects and UC patients, and after stimulation with Pam<sub>3</sub>CSK<sub>4</sub> (ligand of TLR2/1) and MDP-L18 (ligand of NOD2) this difference was maintained, while other microbial stimuli (LPS, ligand of TLR4 and PolyI:C, ligand of TLR3) induced massive activation in CD monocytes as well as in UC and in healthy control cells.
|
27895399 |
2016 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The nucleotide oligomerization domain 2/caspase activating recruitment domain 15 (NOD2/CARD15) gene located at 16q12 is strongly associated with susceptibility to CD in white people but is absent in adult Asian patients, whereas the role of Toll-like receptor 4 (TLR4) polymorphisms has also been reported.
|
17325555 |
2007 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The meta-analysis showed that TLR4 D299G and T399I confer a significant risk for developing CD and UC in Caucasians.
|
20093834 |
2010 |
|
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
The aim of the study was to evaluate associations between inflammatory bowel disease (IBD) presentation and variants in NOD2, TLR4, TNF-α, IL-6, IL-1β, and IL-RN genes in order to identify possible environmental factors that may affect IBD occurrence, investigate potential predictors for surgical treatment of IBD, and correlate the presence of granulomas in biopsy specimens with clinical characteristics of Crohn's disease (CD) patients.
|
28452812 |
2017 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped and tested for case-control frequency differences in a New Zealand white cohort of 389 Crohn's disease (CD) patients, 405 ulcerative colitis (UC) patients, and 416 population controls.
|
17850411 |
2007 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The TLR4 Asp299Gly polymorphism is a risk factor for CD.
|
15973118 |
2005 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Significant associations were found between Crohn's disease (CD) and minor NOD2 variants, as well as TLR4 299Gly, TNF-α G-308A, IL-6 G-174C and IL-1RN VNTR A2 variants, while ulcerative colitis (UC) was associated only with IL-1RN VNTR A2 variants.
|
26316104 |
2015 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of NOD2 (R702W, G908R and L1007fs) and TLR4 (Asp299Gly and Thr399Ile) genes were analyzed in 106 patients with IBD (68 with ulcerative colitis [UC], 38 with Crohn's disease [CD]) and 160 healthy controls using polymerase chain reaction-restriction fragment length polymorphism.
|
29055077 |
2017 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in CARD15 and TLR4 have been linked with Crohn's disease (CD).
|
17504508 |
2007 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Peripheral blood mononuclear cells from healthy individuals and patients with Crohn's disease with different ATG16L1 genotypes were stimulated with ligands for Toll-like receptor 2 (TLR2), TLR4 and nucleotide-binding oligomerisation domain 2 (NOD2), with or without the autophagy inhibitor 3-methyladenine.
|
21406388 |
2011 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis suggests that TLR4 T399I polymorphism is moderately associated with susceptibility to CD, and more studies are needed to confirm our conclusion.
|
29421805 |
2018 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our genotyping of 1539 cases of IBD and pooled analysis of 4805 cases of IBD validates the published association of a TLR4 allele with risk of IBD (odds ratio (OR): 1.30, 95% confidence interval (CI): 1.15-1.48; P=0.00017) and Crohn's disease (OR: 1.33, 95% CI: 1.16-1.54; P=0.000035) but not ulcerative colitis.
|
17538633 |
2007 |
|
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our aim was to investigate whether mutations in various genes other than NOD2/CARD15 or TLR4 associated with CD (NOD1/CARD4, DLG5 and DEFB1) may influence the presence of antibodies against bacterial proteins and carbohydrates in a Hungarian cohort of CD patients.
|
18397186 |
2008 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
One non-synonymous SNP in TLR4 and two non-synonymous SNPs in CARD15, previously associated with atherosclerosis and Crohn's disease, respectively, were also studied.
|
16907704 |
2006 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
NOD2, CD14 and TLR4 mutations do not influence response to adalimumab in patients with Crohn's disease: a preliminary report.
|
21039068 |
2010 |